About Sarah Palin

I was as dumbstruck as most Alaskans were when, on August 29, John McCain announced Sarah Palin as his running mate. And like many Alaskans, I immediately became a source for non-Alaskans about who in heck this person was.

My opinion of her has changed over time.

November 7, 2006: “it’s a sad day in ak”

When she was elected as Alaska’s governor on November 7, 2006, I was pretty unhappy. Can’t say I knew a huge amount about her: chiefly that in the Republican primary she had defeated the nation’s most unpopular governor, Frank Murkowski (along with another Republican candidate), & that she had extremely conservative religious views that translated into extremely conservative social views about abortion, equal rights for LGBTQI folks, etc. Her Democratic opponent, Tony Knowles, was a known quantity — I’d followed his career for years as Anchorage mayor & a two-term governor whose achievements I quite respected, in spite of a couple of issues I’d had with him in the past. But the choice was pretty clear for me. Unfortunately, in a “red” state like Alaska, the lesser-known quantity prevailed. As one of my Flickr contacts wrote, “it’s a sad day in ak.”

Maybe she’s not so bad after all….

But she is. The more I learn about her, the worse it gets. Yuk.

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I want PLAIN truth not PALIN truth. No more lies, Palinochio.


From the Hold Palin Accountable Rally held in Anchorage on September 27, 2008. The rally’s stated purpose was to hold Alaska Governor Sarah Palin accountable for her abuses of power in the Troopergate scandal, & to call for the removal of Talis Colberg as Attorney General.

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A sea change in Alaska?

It’s been nearly a year since I’ve kept up this blog. Decided to start it up again.

Why now? Because I’m an Alaskan, & while I’d never intended this blog as a political blog per se, there’s a lot of political stuff in/about Alaska right now that’s got me riled up. Or something.

Governor Sarah Palin as a VP candidate, & the interference of McCain/Palin campaign flacks in Troopergate. Senator Ted Stevens on trial for corruption in Washington, DC. The possibility that both Ted Stevens & Representative Don Young will get tossed out of office by Anchorage Mayor Mark Begich & former state legislator Ethan Berkowitz, respectively. Alaskans waiting with bated breath for possible indictments of Don Young & Ted Stevens son Ben Stevens. Etc. etc.

A sea change in Alaska? Maybe, just maybe. I’d like to see one, I truly would.

More to come.

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Weight loss chart 18 Feb – 12 Aug 2008

melweightloss

Here it is all in one pretty little chart: my weight loss since February 18 this year (41 pounds scale weight to date). The color swatches mark off the diet regimes I was following during each period. Lotsa jaggies during the TKD & PSMF periods: that’s due to water weight fluctuations from carbs consumed during free meals. But an obvious & very pleasing downward trend.

TKD stands for Targeted Ketogenic Diet — a low-carb diet in which carbs are consumed around workouts. PSMF stands for Protein Sparing Modified Fast — a very low-carb, low-calorie diet designed for maximum loss of bodyfat while preserving (sparing) the body’s protein stores (i.e., muscle). The PSMF regime I follow is from Lyle McDonald’s The Rapid Fat Loss Handbook.

The span of time marked “TKD (Start Walking)” marks when I was following a TKD during the last couple of weeks of meeting the major goals of my workplace Start Walking program — because no way could I have sustained the levels of exercise I was doing on a PSMF!

Oh yeah… & the period of “smooth loss” at the beginning was because I wasn’t weight myself daily then — I started doing that on Apr. 7 after I got a decent scale. (Also didn’t weigh daily during the vacation because I was traveling.) Otherwise, weights were taken daily, so that fluctuations are much more apparent.

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My four-chambered echo chamber

Just had my echocardiogram over at Heart Center at Providence Hospital. This is one of the three imaging tests the ER doctor from my pepperoni pizza night ordered up to figure out whether I had a TIA or not — in this case an ultrasound of my heart. The technician, his name was Michael, was really good, & so was the guy (damn did I forget his name?) who set me up with the saline IV for the last part of the test.

And it was also pretty cool, & scary in a weird kinda way, to see those images of my heart pumping away on that black & white screen. Whoa, you’ve really been doing this job for 49 years plus? And so well, too. Don’t stop, please!

Michael is the tech (I guess they call them cardiac sonographers), not the cardiologist, but he said that everything looked pretty good & normal. Nothing in what he saw to indicate that a TIA, if there indeed was one, came about because of any heart stuff.

Good job, heart.

Still a carotid doppler ultrasound & MRI to go, tomorrow.

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Um… pepperoni…?

Last month, on a day that happened to coincide (& undoubtedly not just coincidentally) with a bit of constipation plus an abnormally-for-me high level of sodium intake from eating too many meals in a row that featured ham — well, on that day I had a couple of incidents of a weird visual effect like seeing heat waves all around the peripheral vision of my right eye, couple with a really hard time focusing the two eyes together for reading. Second time it happened, it was followed on by a nagging headache just behind my left eye. It was only a couple of weeks ago that my friend Chris suggested that I’d experienced a migraine headache. Well, duh, Mel — but I’ve never gotten migraines before, so…. In my case I think it was caused by high blood pressure from water retention do to constipation plus too much ham. 😉

Didn’t eat any ham yesterday, but lo! just after work while sitting on the bus reading a book, I started having some visual symptoms that at first had me thinking I was experiencing the same thing. Mostly inability to get my eyes to work together to focus on the page for reading. After I got across town to the restaurant I’d decided to eat at (the Bear Tooth, my fave), I started realizing it was different. First of all — well, the place wasn’t crowded, so I knew they had they’re “Please Be Seated” sign out. Except when I looked at it, I couldn’t make sense of it. It reminded me of when Jesse was learning to read & had big problems with blends — like being unable to connect the B and the L together in BLUE or BLACK (or BLEND). In my case I could read the three individual words PLEASE, SEAT, & YOURSELF, but I couldn’t make them make sense together. I only understood what it meant from having been there before & logicking it out.

So went & sat myself, knowing exactly what I wanted to order.— I didn’t even need. to look at the menu — except that I couldn’t remember the words for what I wanted. So I got the menu & started researching — again, being able to read individual words, but being able to connect them with each other, except just for the fact that I eat there a lot so logically know what’s what. The server came & asked me if I’d like something to drink. By that time I’d managed to puzzle out the beer I wanted (Bear Tooth had great microbrews), so I said IPA. She asked if I was also ready to order food, & I said I was, except that… I wasn’t. I couldn’t find the words. I said so: I lost the words. She laughed, not unkindly, until she became aware that I was distressed. I think she used the word “aphasia.” I said, yes, & ended up asking her to come back in a couple of minutes. I needed to do research in the menu.

It was incredibly weird. I wanted one piece of pepperoni pizza, plus an entree size Caesar salad w/ grilled chicken. But I couldn’t remember the words at all. I knew where they were on the menu, though, so I turned to the pizza page, found the word “Pizza” on the top, knew with some intellectual effort that was the right word, but had absolutely emotional sense of it: it was just a data point. Scan down the page… pepperoni?… yes… pepperoni. Memorized it, so that by the time the waitress got back I could order it. I knew how to add in “one piece” without the menu’s coaching, though. Then… salad. This one, the Caesar. With… chicken. And this size — yes the word is… entree. While noting to her again that something pretty darn weird was happening to me.

I was freaking, really… wondering if something had happened such that I wouldn’t be able to hold my job anymore, wouldn’t even be able to read a book. Got out my book & studied it — could read words, could even read sentences, none of ’em made sense. The food came, I put the book aside, sat there chomping my pizza all the time trying to remember again what this food was called that I was eating. Pizza…? yes, that seemed right. But what were these round red slices of meat on it called? I spent half the meal trying to remember, before I finally gave up & looked it up again at the back of the menu. Put the words together, repeated them & repeated them, memorizing it. Then worked on the name of the salad. Looked around the place which (as it’s part of an establishment including a movie theatre) has several old movie posters, including one from a foreign country of the old Peter Fonda movie “Easy Rider.” I had seen that poster enough to have no problem with his name. But what was that last one? Jack. Nicholson. Jack. Nicholson. Is that somebody… is that that guy from [images of “Chinatown” in my mind] — was that the guy? Jack… Nicholson….?

But, I was able to pay my bill without a hitch & even get the tip right. And by the time I’d left the building, put the hood up on my raincoat, stuck my Bluetooth in my ear, & started off home in the rain while talking w/ my friend Marcia, things began getting normal again. I could say, without a hitch, pepperoni pizza & entree-size chicken Caesar salad & Jack Nicholson & Please Seat Yourself without a hitch.

Marcia told me she was coming to pick me up to take me to the emergency room.

Um… you are?—But yes, after some discussion & argument, also with another friend of mine, that’s what happened. Spent nearly 4 hours at Providence Hospital ER last night — just across the street from my work, in fact just across the parking lot from the very bus stop where the whole biz began to unfold after work yesterday.

The current theories are either (1) hypgoglycemia, some hours after eating an oatmeal raisin cookie (although I’m low-carbing at the moment, I’ve been having some depression issues for a couple of days, & carbs help — which was also the point with the… uh… what was that food with the little red slices of meat again?); or (2) a transient ischemic event, TIA — AKA a “mini-stroke.” Which frankly I’d never heard of before last night.

My EKG was fine. Other tests up & coming — an echocardiogram tomorrow, an MRI & carotid doppler ultrasound Friday, a followup “what does this MEAN?!!” with my naturopath the following Friday.

Meantime, nothing like a little cognitive confusion & adrenaline to wipe out the last vestiges of the latest brief venture into depression.

Pepperoni pizza!

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Adverse weather conditions

Per the UPS tracking site, my Xvest underwent adverse weather conditions in Anchorage at 8:09 PM last night. But today, it’s officially been arrival-scanned into Anchorage. Hope they deliver it tomorrow early enough for the kid to sign for it before he heads to work.

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Xvest

I ordered an Xvest.

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More on d-chiro inositol

DCI has been shown to work orally at least in PCOS, Type 2 diabetes, & general insulin resistance, both in human studies & anecdotally. Anecdotally, d-pinitol (Inzitol) is getting some attention in athletic/bodybuilder circles.

d-chiro-inositol

One of the central studies seems to be one in the New England Journal of Medicine (Nester, et al. Ovulatory and metabolic effects of d-chiro-inositol in the polycystic ovary syndrome. New England Journal of Medicine 340 (1999): 1314-1320). They used 1200 mg. oral doses of D-chiro-inositol in the form of a product-in-development called INS-1 from Insmed Pharmaceuticals. 22 women with PCOS were matched against a placebo group of 22 women also with PCOS. Conclusions: “D-Chiro-inositol increases the action of insulin in patients with the polycystic ovary syndrome, thereby improving ovulatory function and decreasing serum androgen concentrations, blood pressure, and plasma triglyceride concentrations.”

More research: Insmed was developing INS-2 for use in PCOS, diabetes, & dyslipidemia (high blood lipids) & ran Phase II clinical trials in 2001-2002. But they discontinued development of INS-2 in Sept. 2002, saying that “INS-1 was safe and well tolerated but did not achieve statistical significance on its primary efficacy measures” — in spite of earlier press releases about the same trials that said there were statistically significant improvements (in Type 2 diabetes; in obese women w/ PCOS & nondiabetics with dyslipidemia). Anecdotally, women on the Soulcysters PCOS board reported participating in the clinical trials & experiencing big improvements on INS-1 — for example, regular periods (which sometimes go by the slang term “AF” meaning “Aunt Flo”) & ovulation, lower hirsutism, better skin, no more hypoglycemia — improvements that disappeared after the trials ended & they were no longer getting the INS-1. People have also reported better weight loss. All of which makes me think that Insmed’s decision to discontinue was premature. It sure was from the POV of PCOS-sufferers. (I’m not trying to get preggers myself, but a lot of women with PCOS are, & inability to have periods or to ovulate creates a problem.)

Anecdotally, women at Soulcysters say that eating food sources of d-chiro-inositol such as “PCOS-blaster” muffins containing buckwheat bran brings improvements, & so do the oral DCI supplements from the company Chiral Balance. Chiral Balance is a small company run, I gather, by a couple of biochemists who seem to be approaching DCI supplementation from a nutritional supplement rather than drug/pharmaceutical angle. Unfortunately, it’s still expensive, & nutritional supplements aren’t usually covered by health insurance.

Other studies in humans with related to DCI — Iuorno et al. 2002 (DCI supplementation in PCOS); Baillargeon et al. 2004 (metformin for PCOS seems to increase DCI-containing inositolphosphoglycan). There still seems to be a lot of study of DCI’s mechanisms in insulin metabolism in mice & other animals too.

D-pinitol

An alternative oral supplement is d-pinitol (3-O-methyl-chiroinositol) — which it seems d-chiro-inositol can easily be made from, possibly even in insulin resistant people. (I’m still trying to understand the science — I’m smart enough I guess, but not a biochemist.) Pinitol is found in high concentrations in some legumes (such as soy), plants, fruits, and parts of pine trees like the sugar pine. Two manufactured supplements containing it: Inzitol & ViTAL Nutrients d-Pinitol 600. (About $120 per 60-cap bottle on Amazon — just about as expensive as Chiral Balance’s DCI. But $79.95/bottle at this point from this source.)

Inzitol is found in a product called Meta-Cel, which also contained creatine & is aimed at bodybuilders. Also apparently in another bodybuilder supplement called Nitro-Tech that makes all kinds of (who knows if they’re valid) claims. Also apparently in some products from PVL Nutrients, but it’s not readily apparent which ones. A Google search on Inzitol brings up a lot of hits about the use of Inzitol in athletics, including bodybuilding, where it’s alleged to help with creatine utilization. E.g., this interview with someone at the New Zealand company that makes Inzitol.

In one human study on pinitol I found in PubMed, pinitol was found to increase levels of d-chiro-inositol in the body (14-fold increase in DCI levels with 20 mg pinitol per kg of body weight per day for four weeks in diabetic patients), but not to improve insulin sensitivity (Davis et al. 2000). Another found it didn’t help insulin sensitivity in nondiabetic older people (Campbell et al. 2004). On the other hand, Kim et al. 2007, in a study of poorly controlled Type 2 diabetics, found “fasting glucose, post-prandial glucose levels, and hemoglobin A1c were significantly decreased.” Similarly, Kang et al. 2006. (Both these latter two studies uses pinitol from soy sources, not sure what the other studies used. I believe Inzitol is manufactured from pine tree sources.)

Mechanism

From the best I understand, the proven low levels of d-chiro-inositol in Type 2 diabetics & women w/ PCOS (& other insulin resistant people) appears to be a deficiency caused by an inability to transform myo-inositol into d-chiro-inositol within the body. Whether that’s from some sort of genetic problem or due to environment (hyperglycemia &/or hyperinsulinemia, perhaps) isn’t clear. But I’m thinking it’s quite similar to how we as human beings are supposed to be able to change the omega-3 DHA found in flax seed into the essential omega-3s EPA & DHA. But, we’re pretty inefficient at it, & many people can’t seem to do it at all, so therefore we eat fish oil in order to get enough EPA/D
HA
. Most people can make DCI in their own bodies, but insulin resistant people’s bodies are lousy at it; so we need supplementation.

So… this might not have that much utility as I thought it might for insulin sensitive dieters, who probably don’t have this deficiency… but for those of us who are insulin resistant, & eating moderate to high-carb diets, it might be very helpful indeed. Meantime, the bodybuilder supplement industry seems to be embracing Inzitol, though whether it’s anything more than something else to make money with — in an industry that sells all kinds of expensive supplements that may or may not be beneficial for the purposes advertised — is a question.

At any rate, for anyone who wants to experiment, seems that both DCI & pinitol are different from Metformin (glucophage) as insulin-sensitizers in that they are naturally found in the human body, & all reports seem to be that oral supplementation is well-tolerated & doesn’t give the nasty side effects Metformin sometimes does.

According to Joseph Larner, who’s been studying d-chiro-inositol for a couple of decades, DCI was “originally discovered as a component of a putative mediator of intracellular insulin action, where as a putative mediator, it accelerates the dephosphorylation of glycogen synthase and pyruvate dehydrogenase, rate limiting enzymes of non-oxidative and oxidative glucose disposal.” Further explained, most of it understandable even to non-biochemist-me, in the journal article of his I posted yesterday, D-chiro-inositol – its functional role in insulin action and its deficit in insulin resistance. International Journal of Experimental Diabetes Research 3(1) (2002): 47-60.

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D-chiro inositol

Yesterday on an email list I’m on, someone mentioned d-chiro-inositol (DCI) (part of the B-vitamin group), which I’d never heard of before, but which plays a part in carbohydrate metabolism as some sort of helper to insulin. It turns out insulin resistant/Type 2 diabetic people in general, & women with polycystic ovarian syndrome (PCOS) in particular (which affects about 10% of all women, including me), have been found to have deficient levels of DCI in their bodies.

It’s theorized that this is due to an impairment in whatever it takes for the closely related myo-inositol to be changed into d-chiro-inositol in the body. Furthermore, studies have shown that women with PCOS & Type 2 diabetics who are given supplements of DCI have improvements in insulin sensitivity, blood sugar levels, blood insulin levels, etc. — as well as improvement of the additional symptoms (high androgen levels, irregular to nonexistent menstrual periods, infertility) that tend to accompany PCOS. On an anecdotal level, there are a number of women at the forums at Soulcysters.com (a major PCOS support site) who report having successfully regulated their menstrual cycles & achieving pregnancy (as well as other improvements) through supplementation with DCI. The word “miracle” tends to show up. (Well, I guess miracles do happen when deficiencies are addressed. That’s how sailors must’ve felt when they learned all they had to keep from getting scurvy was to eat citrus fruits.)

Here’s some relevant studies. All of these have full-text available online:

Unfortunately there are few sources of DCI supplements, & they tend to be expensive (e.g., Chiral Balance). Apparently the mega-pharmaceutical companies haven’t found it worth their while to bring their own versions to market. Less expensive supplements called simply inositol or myo-inositol seem to be helpful for some people, but since the problem insulin resistant people seem to have is in changing myo-inositol to DCI, it’s really DCI that needs to be supplemented. Another supplement that might work, though, is d-pinitol (aka D-chiro (+)-o-methyl inositol), which is available under the trade name Inizitol (New Zealand company, but there are distributors in the U.S. & Canada); this is also recommended as a possible supplement for PCOS by Richard Bernstein in Dr. Bernstein’s Diabetes Solution. Apparently d-pinitol is also used a lot by athletes and affects whole-body creatine retention. More info on d-pinitol & DCI from a PCOS-suppement supplier here.

The food source with the highest level of DCI is buckwheat (which is actually a rhubarb relative, not a grain), especially in buckwheat bran (farinetta) (available in quantity from Minndak.com). Apparently some other legumes (e.g., garbanzo beans) also contain small quantities of DCI. People at Soulcysters, who have become quite expert at creating recipes containing these foods, have also mentioned carob syrup & soy lecithin — I think those are supposed to be sources of pinitol. Carob syrup is something of a problem since it’s got a lot of sugar.

… Since I’m insulin resistant & have PCOS, I probably have this deficiency in d-chiro-inositol, so I am likely going to get some of this stuff no matter how expensive & experiment with it when I get back from my trip.

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